The buildup of uric acid crystals in the joints, which results in severe inflammation, is the primary cause of arthritis gout. Indomethacin is one of the most often prescribed drugs for gout. Indomethacin is often recommended for the treatment of gout, however, many medical professionals are hesitant to do so. In this article, we examine the reasons why indomethacin gout is not recommended as the first line of treatment.
What Is Indomethacin?
Nonsteroidal anti-inflammatory drugs (NSAIDs) like indomethacin are frequently used to treat gout. It functions by lowering pain and swelling in the injured joint. There are several ways to take indomethacin, including pills, capsules, and suppositories.
Why Is Indomethacin Not The First Choice For Gout Treatment?
- High Risk of Side Effects: The increased risk of adverse effects is one of the primary reasons doctors are reluctant to recommend indomethacin for gout. Indomethacin, like all NSAIDs, can lead to gastrointestinal issues such as stomach ulcers, bleeding, and perforation. Other negative side effects include headaches, vertigo, and skin rashes.
- Contraindications: Not everyone should take indomethacin. People with a history of stomach bleeding, peptic ulcers, renal illness, heart disease, and high blood pressure should not take it. Additionally, it is not advised for those who are expecting, nursing or have a history of asthma.
- Lack Of Efficacy: According to studies, indomethacin may not be as helpful in treating gout pain as other drugs. For instance, a 2018 research indicated that the steroid drug prednisolone was superior to indomethacin in relieving gout pain.
- Limited Duration Of Use: Due to the possibility of negative effects, long-term usage of indomethacin is not advised. It needs to be used for just a little time, often no longer than two weeks. Its efficacy in treating chronic gout is therefore constrained.
What Are The Alternatives To Indomethacin Gout?
- Colchicine: Anti-inflammatory drug colchicine is frequently prescribed to treat gout. It functions by lessening the swelling brought on by uric acid crystals. When NSAIDs are either prohibited or inefficient for treating gout, colchicine is frequently used as a second-line therapy.
- Steroids: Prednisolone and methylprednisolone are two powerful anti-inflammatory drugs that work well to treat gout discomfort. When NSAIDs and colchicine are contraindicated or ineffective, they are frequently used.
- Urate-Lowering Therapy: A long-term gout treatment called uric acid-lowering therapy seeks to diminish the amount of uric acid in the blood. Medications like allopurinol and febuxostat can help with this. The risk of gout complications can be decreased and future gout episodes can be reduced by uric acid-lowering medication.